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Will utilize Manifold’s mDesign drug discovery engine and tissue-targeting shuttle portfolio to create blood-brain barrier shuttles for multiple brain-targeted therapeutic modalities.
November 3, 2025
By: Charlie Sternberg
Associate Editor
Roche Holding AG has entered into a strategic research collaboration and licensing agreement with Manifold Bio, a Boston-based biotechnology firm specializing in AI-guided drug discovery and in vivo measurement technologies. The partnership aims to develop next-generation blood-brain barrier (BBB) shuttles to enhance delivery of therapeutics for neurological and neurodegenerative diseases. Under the terms of the agreement, Manifold will receive an upfront payment of $55 million and is eligibl...
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